Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection

G-quadruplexes contribute to the regulation of key molecular processes. Their utilization for antiviral therapy is an emerging field contemporary research. Here we present comprehensive analyses presence and localization putative G-quadruplex forming sequences (PQS) in all viral genomes currently available NCBI database (including subviral agents). The G4Hunter algorithm was applied a pool 11,000 accessible representing 350 Mbp total. PQS frequencies differ across evolutionary groups viruses, are enriched repeats, replication origins, 5?UTRs 3?UTRs. Importantly, connected lifecycles corresponds type infection rather than nucleic acid type; while viruses routinely causing persistent infections Metazoa hosts PQS, acute significantly depleted PQS. unique identifies importance G-quadruplex-based life cycle, providing tool potential therapeutic targeting.